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Discussion Cellular senescence has been implicated in various biological processes including cancer and tissue repair

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These metabolic benefits translate into whole-body effects: for example, in diet-induced obesity models, MOTS-c administration prevented excessive weight gain and insulin resistance when mice were fed a high-fat diet, without affecting weight in lean diets

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Additionally, DSIP attenuates ACTH and corticosterone release in response to stress, indicating an effect on the hypothalamic-pituitary-adrenal axis